Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845821 | 0.91 | ALDH1A1 (0.58) | ALDH1A1LMNAKMT2AMEN1RECQL | |
| SCHEMBL14601545 | 0.89 | ALDH1A1 (0.63) | ALDH1A1LMNAKMT2AMEN1RECQL | |
| SCHEMBL5678530 | 0.87 | ALDH1A1 (0.61) | ALDH1A1LMNAKMT2AMEN1RECQL | |
| SCHEMBL2436211 | 0.83 | ALDH1A1 (0.79) | ALDH1A1LMNAKMT2AMEN1RECQL | |
| SCHEMBL30159613 | 0.83 | ALDH1A1 (0.79) | ALDH1A1LMNAKMT2AMEN1RECQL | |
| SCHEMBL10507215 | 0.82 | ALDH1A1 (0.77) | ALDH1A1LMNAKMT2AMEN1RECQL | |
| SCHEMBL10507211 | 0.82 | ALDH1A1 (0.77) | ALDH1A1LMNAKMT2AMEN1RECQL | |
| SCHEMBL11052582 | 0.81 | ALDH1A1 (0.57) | ALDH1A1LMNAKMT2AMEN1RECQL | |
| SCHEMBL6063920 | 0.80 | ALDH1A1 (0.53) | ALDH1A1LMNAKMT2AMEN1RECQL | |
| SCHEMBL5678528 | 0.79 | ALDH1A1 (0.59) | ALDH1A1LMNAKMT2AMEN1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432555-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135650-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2010-11-25 | — | — | WO | disclosed |