Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 10/20 | 0.63 |
| ▸ | RXRB | P28702 | 4/20 | 0.63 |
| ▸ | RXRG | P48443 | 4/20 | 0.63 |
| ▸ | RARB | P10826 | 14/20 | 0.55 |
| ▸ | RARG | P13631 | 12/20 | 0.55 |
| ▸ | RARA | P10276 | 10/20 | 0.55 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9483542 | 0.85 | RARB (0.71) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9483271 | 0.83 | RXRA (0.41) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL6244149 | 0.77 | RXRA (1.00) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL22824265 | 0.76 | RARB (0.56) | RXRARXRBRARBRARGRARA | |
| SCHEMBL9487042 | 0.76 | RARB (0.67) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9551744 | 0.75 | RXRA (0.63) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL6904473 | 0.75 | RXRA (1.00) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL6244147 | 0.74 | RARB (0.74) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9484739 | 0.74 | RXRA (0.59) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9713981 | 0.74 | RARB (0.69) | RXRARXRBRXRGRARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |
| US-5256694-A | For skin disorders; carcinomas | BASF AKTIENGESELLSCHAFT (DE) | 1993-10-26 | — | — | US | disclosed |
| US-5126371-A | Precancerous skin conditions, acne, psoriasis | BASF AKTEINGESELLSCHAFT (DE) | 1992-06-30 | — | — | US | disclosed |
| US-4994489-A | Ester derivatives of diarylacetylenes, their compositions and their use in acne treatment | BASF AKTIENGESELLSCHAFT | 1991-02-19 | — | — | US | disclosed |
| US-4806558-A | Diarylacetylenes and their use in treating acne | BASF AKTIENGESELLSCHAFT (DE) | 1989-02-21 | — | — | US | disclosed |