Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.61 |
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | PIM1 | P11309 | 2/20 | 0.59 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.59 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8458670 | 1.00 | PPARG (0.61) | PPARGHPGDPIM1PIM2GPR35 | |
| SCHEMBL9122231 | 0.88 | CSNK2A2 (0.50) | PPARGHPGDPIM1PIM2GPR35 | |
| SCHEMBL9536301 | 0.86 | HPGD (0.64) | PPARGHPGDPIM1PIM2GPR35 | |
| SCHEMBL9536304 | 0.86 | HPGD (0.64) | PPARGHPGDPIM1PIM2GPR35 | |
| SCHEMBL9121091 | 0.85 | HPGD (0.64) | PPARGHPGDPIM1PIM2GPR35 | |
| SCHEMBL9123327 | 0.85 | HPGD (0.64) | PPARGHPGDPIM1PIM2GPR35 | |
| SCHEMBL9124668 | 0.84 | HPGD (0.68) | PPARGHPGDPIM1PIM2PTPN1 | |
| SCHEMBL9124675 | 0.84 | HPGD (0.68) | PPARGHPGDPIM1PIM2PTPN1 | |
| SCHEMBL9327162 | 0.83 | PPARG (0.80) | PPARGHPGDPIM1PIM2PTPN1 | |
| SCHEMBL9327166 | 0.83 | PPARG (0.80) | PPARGHPGDPIM1PIM2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999059586-A1 | THIAZOLIDINE AND OXAZOLIDINE DERIVATIVES FOR THE TREATMENT OF ACUTE MYOCARDIAL INFARCTION AND INHIBITION OF CARDIOMYOCYTE APOPTOSIS | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-11-25 | — | — | WO | claimed |
| US-5478851-A | Hyperglycemic agent and antilipemic agent | BEECHAM GROUP PLC (GB) | 1995-12-26 | — | — | US | claimed |
| EP-0555264-A1 | NOVEL COMPOUNDS | BEECHAM GROUP plc (GB) | 1993-08-18 | — | — | EP | claimed |
| WO-1992007850-A1 | NOVEL COMPOUNDS | BEECHAM GROUP PLC (GB) | 1992-05-14 | — | — | WO | claimed |
| WO-1999059586-A1 | THIAZOLIDINE AND OXAZOLIDINE DERIVATIVES FOR THE TREATMENT OF ACUTE MYOCARDIAL INFARCTION AND INHIBITION OF CARDIOMYOCYTE APOPTOSIS | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-11-25 | — | — | WO | disclosed |
| US-5478851-A | Hyperglycemic agent and antilipemic agent | BEECHAM GROUP PLC (GB) | 1995-12-26 | — | — | US | disclosed |