Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | CFD | P00746 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | GPR3 | P46089 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23537498 | 0.83 | PARP1 (0.45) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL29824598 | 0.83 | PARP1 (0.45) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL22122397 | 0.78 | METAP2 (0.40) | HSD17B10MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL31027151 | 0.77 | DYRK1A (0.58) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2220752 | 0.77 | DYRK1A (0.58) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL30451928 | 0.77 | KDM4E (0.50) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4287798 | 0.77 | KDM4E (0.50) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5830601 | 0.74 | HTT (0.50) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7441456 | 0.74 | KDM4E (0.60) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL14895777 | 0.70 | ALDH1A1 (0.53) | HSD17B10MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3897644-A1 | COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF | Revolution Medicines, Inc. (US) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020132597-A1 | COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF | Revolution Medicines, Inc. (US) | 2020-06-25 | — | — | WO | disclosed |
| EP-0923552-A1 | PYRANOINDOLE AND CARBAZOLE INHIBITORS OF COX-2 | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-06-23 | — | — | EP | disclosed |
| US-5824699-A | COMPOUNDS FOR TREATMENT OF ARTHRITIS, COLORECTAL CANCER AND ALZHEIMER'S DISEASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-10-20 | — | — | US | disclosed |
| US-5776967-A | ANTIINFLAMMATORY AGENTS; THERAPY FOR ARTHRITIC DISORDERS, COLORECTAL CANCER AND ALZHEIMER'S DISEASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-07-07 | — | — | US | disclosed |
| WO-1998004527-A1 | PYRANOINDOLE AND CARBAZOLE INHIBITORS OF COX-2 | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |