Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.35 |
| ▸ | MMP7 | P09237 | 4/20 | 0.35 |
| ▸ | MMP12 | P39900 | 4/20 | 0.35 |
| ▸ | MMP13 | P45452 | 4/20 | 0.35 |
| ▸ | ACE | P12821 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15825362 | 0.84 | TSHR (0.36) | MMP1MMP7MMP12MMP13ACE | |
| SCHEMBL11652838 | 0.82 | TSHR (0.34) | MMP1MMP7MMP12MMP13ACE | |
| SCHEMBL3365927 | 0.81 | CA2 (0.36) | TSHRALDH1A1SMN1; SMN2CA1CA2 | |
| SCHEMBL368530 | 0.81 | TSHR (0.33) | MMP1MMP7MMP12MMP13ACE | |
| SCHEMBL88231 | 0.81 | TP53 (0.37) | MMP1MMP7MMP12MMP13ACE | |
| Ammonia Solution, Strong SCHEMBL1646990 | 0.79 | TP53 (0.36) | MMP1MMP7MMP12MMP13ACE | |
| SCHEMBL9514472 | 0.79 | MMP1 (0.34) | MMP1MMP7MMP12MMP13ACE | |
| SCHEMBL7125310 | 0.79 | MMP1 (0.34) | MMP1MMP7MMP12MMP13ACE | |
| SCHEMBL10348720 | 0.77 | MMP1 (0.36) | MMP1MMP7MMP12MMP13ACE | |
| SCHEMBL3318223 | 0.77 | CA2 (0.37) | TSHRALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | claimed |
| US-5707989-A | ANTITUMOR AGENTS, INHIBITING SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES | DR. KARL THOMAE GMBH (DE) | 1998-01-13 | — | — | US | claimed |
| US-5707989-A | ANTITUMOR AGENTS, INHIBITING SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES | DR. KARL THOMAE GMBH (DE) | 1998-01-13 | — | — | US | disclosed |