Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 8/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 12/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 11/20 | 0.55 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490103 | 0.93 | ITGB3 (0.53) | ITGAVITGB3ITGA2B | |
| SCHEMBL8903718 | 0.93 | ITGB3 (0.53) | ITGAVITGB3ITGA2B | |
| SCHEMBL8902514 | 0.90 | ITGAV (0.52) | ITGAVITGB3ITGA2BPSMB8PSMB5 | |
| SCHEMBL7486439 | 0.85 | ITGB3 (0.60) | ITGAVITGB3ITGA2B | |
| SCHEMBL7377406 | 0.85 | ITGB3 (0.48) | ITGAVITGB3ITGA2BPSMB8 | |
| SCHEMBL6493323 | 0.85 | ITGB3 (0.48) | ITGAVITGB3ITGA2B | |
| SCHEMBL6492757 | 0.85 | ITGB3 (0.48) | ITGAVITGB3ITGA2B | |
| SCHEMBL7493829 | 0.84 | ITGB3 (0.61) | ITGAVITGB3ITGA2B | |
| SCHEMBL7495217 | 0.84 | ITGB3 (0.54) | ITGAVITGB3ITGA2B | |
| SCHEMBL383058 | 0.83 | ITGB3 (0.58) | ITGAVITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929120-A | Guainidino, formamidino, amino and related compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1999-07-27 | — | — | US | disclosed |
| US-5741796-A | Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1998-04-21 | — | — | US | disclosed |