Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.44 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | FABP6 | P51161 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27418792 | 0.79 | CHRNB2 (0.44) | HTTBCHEACHEBACE1DPP7 | |
| SCHEMBL10725756 | 0.79 | SIGMAR1 (0.44) | HTTGAABCHEACHEBACE1 | |
| Hydrochloric Acid SCHEMBL27284977 | 0.78 | CHRNB2 (0.42) | HTTDPP7 | |
| Hydrochloric Acid SCHEMBL27395800 | 0.78 | CHRNB2 (0.42) | HTTDPP7 | |
| SCHEMBL8453440 | 0.78 | HTT (0.48) | HTTNPC1RAB9ACXCR4HPGD | |
| SCHEMBL8646121 | 0.77 | HTT (0.40) | HTTNPC1RAB9ACXCR4BCHE | |
| SCHEMBL9840998 | 0.73 | KMT2A (0.47) | HTTGAACXCR4ALDH1A1HPGD | |
| SCHEMBL10700286 | 0.73 | KMT2A (0.47) | HTTGAACXCR4ALDH1A1HPGD | |
| SCHEMBL9841000 | 0.73 | DPP4 (0.42) | GAANPC1RAB9ANPSR1CXCR4 | |
| Hydrochloric Acid SCHEMBL8843540 | 0.73 | HTT (0.44) | HTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925302-A1 | PALLADIUM CATALYZED INDOLIZATION | Merck & Co., Inc. (US) | 1999-06-30 | — | — | EP | claimed |
| WO-1998006725-A1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO., INC. (US) | 1998-02-19 | — | — | WO | claimed |