Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874904 | 0.86 | MAPT (0.45) | HPGDCYP1A2CYP3A4CYP2C19RAB9A | |
| SCHEMBL27373324 | 0.84 | HPGD (0.45) | HPGDCYP1A2CYP3A4CYP2C19RAB9A | |
| SCHEMBL27393640 | 0.82 | ALOX15 (0.39) | RAB9ANPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL11289155 | 0.80 | HPGD (0.59) | HPGDCYP1A2CYP3A4CYP2C19RAB9A | |
| SCHEMBL27534594 | 0.80 | HPGD (0.40) | HPGDCYP1A2CYP3A4CYP2C19RAB9A | |
| SCHEMBL27371673 | 0.75 | HPGD (0.44) | HPGDCYP1A2CYP3A4CYP2C19RAB9A | |
| SCHEMBL7868349 | 0.75 | MAPT (0.46) | HPGDCYP1A2CYP3A4CYP2C19LMNA | |
| SCHEMBL27629164 | 0.74 | HPGD (0.53) | HPGDCYP1A2CYP3A4CYP2C19RAB9A | |
| Alcohol SCHEMBL27634214 | 0.74 | HPGD (0.56) | HPGDCYP1A2CYP3A4CYP2C19RAB9A | |
| Piperidine SCHEMBL27676244 | 0.73 | HPGD (0.49) | HPGDCYP1A2CYP3A4CYP2C19RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1084747-C | Pyrrolobenzazepine * derivatives as neuroactive agents | ZENECA LTD (GB) | 2002-05-15 | — | — | CN | disclosed |
| CN-1224424-A | Azolobenzazepine derivs. as neurologically active agents | ZENECA LTD (GB) | 1999-07-28 | — | — | CN | disclosed |
| EP-0888350-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032883-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1997-09-12 | — | — | WO | disclosed |