Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6430723 | 0.81 | USP2 (0.41) | GRM5KDM4EKMT2AGAAPARP1 | |
| Methyl Alcohol SCHEMBL27467514 | 0.79 | PARP1 (0.60) | KDM4EKMT2AGAAPARP1L3MBTL1 | |
| Chloromethane SCHEMBL4962643 | 0.79 | PARP1 (0.60) | KDM4EKMT2AGAAPARP1L3MBTL1 | |
| SCHEMBL1259 | 0.78 | PARP1 (0.64) | KDM4EKMT2AGAAPARP1L3MBTL1 | |
| SCHEMBL4370629 | 0.78 | PARP1 (0.64) | KDM4EKMT2AGAAPARP1L3MBTL1 | |
| SCHEMBL29351761 | 0.78 | PARP1 (0.64) | KDM4EKMT2AGAAPARP1L3MBTL1 | |
| Methoxymethane SCHEMBL4682116 | 0.77 | PARP1 (0.58) | GRM5KDM4EKMT2AGAAPARP1 | |
| Hydrochloric Acid SCHEMBL8503466 | 0.77 | PARP1 (0.62) | KDM4EKMT2AGAAPARP1L3MBTL1 | |
| SCHEMBL11613703 | 0.77 | PARP1 (0.62) | KDM4EKMT2AGAAPARP1L3MBTL1 | |
| SCHEMBL31245780 | 0.77 | PARP1 (0.62) | KDM4EKMT2AGAAPARP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432555-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135650-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2010-11-25 | — | — | WO | disclosed |