Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846079 | 0.85 | NPC1 (0.43) | MAPT | |
| SCHEMBL846445 | 0.83 | KDM4E (0.48) | KDM4EFAAH | |
| SCHEMBL845795 | 0.81 | HCAR2 (0.43) | — | |
| SCHEMBL845796 | 0.81 | HCAR2 (0.43) | — | |
| SCHEMBL846996 | 0.79 | KDM4E (0.42) | ACHEKDM4EFAAHEPHX1 | |
| SCHEMBL846565 | 0.70 | SMN1; SMN2 (0.47) | KDM4EFAAHMAPT | |
| SCHEMBL845800 | 0.69 | TRPV1 (0.59) | KDM4EMAPT | |
| SCHEMBL29238374 | 0.68 | MAPT (0.57) | KDM4EMAPT | |
| SCHEMBL846653 | 0.66 | KDM4E (0.46) | KDM4EFAAHMAPT | |
| SCHEMBL845811 | 0.66 | MEN1 (0.49) | KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |