Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846002 | 0.85 | ACHE (0.45) | MAPT | |
| SCHEMBL845795 | 0.83 | HCAR2 (0.43) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL845796 | 0.83 | HCAR2 (0.43) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL845800 | 0.82 | TRPV1 (0.59) | NPC1RAB9ATP53TRPV1MAPT | |
| SCHEMBL846606 | 0.82 | NPC1 (0.42) | NPC1RAB9ATP53RORC | |
| SCHEMBL846141 | 0.77 | MAPT (0.42) | NPC1TP53POLBTRPV1MEN1 | |
| SCHEMBL846284 | 0.75 | RAB9A (0.57) | NPC1RAB9ATP53POLBMEN1 | |
| SCHEMBL846514 | 0.73 | TRPV1 (0.68) | NPC1RAB9ATRPV1MEN1KMT2A | |
| SCHEMBL846515 | 0.72 | TRPV1 (0.48) | NPC1RAB9ATRPV1MEN1KMT2A | |
| SCHEMBL845758 | 0.71 | KDM4E (0.46) | RAB9APOLBMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |