Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.45 |
| ▸ | FAAH | O00519 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846565 | 0.87 | SMN1; SMN2 (0.47) | KDM4ENPC1SMN1; SMN2HSD17B10TP53 | |
| SCHEMBL845800 | 0.84 | TRPV1 (0.59) | KDM4ENPC1SMN1; SMN2HSD17B10TP53 | |
| SCHEMBL846002 | 0.83 | ACHE (0.45) | KDM4EFAAH | |
| SCHEMBL846407 | 0.83 | NPC1 (0.47) | KDM4ENPC1SMN1; SMN2HSD17B10TP53 | |
| SCHEMBL846869 | 0.81 | NOTUM (0.50) | KDM4ENPC1SMN1; SMN2HSD17B10TP53 | |
| SCHEMBL847501 | 0.81 | KDM4E (0.48) | KDM4ENPC1SMN1; SMN2HSD17B10TP53 | |
| SCHEMBL846653 | 0.81 | KDM4E (0.46) | KDM4ENPC1SMN1; SMN2HSD17B10TP53 | |
| SCHEMBL845811 | 0.81 | MEN1 (0.49) | KDM4ENPC1SMN1; SMN2HSD17B10TP53 | |
| SCHEMBL846654 | 0.81 | KDM4E (0.46) | KDM4ENPC1SMN1; SMN2HSD17B10TP53 | |
| SCHEMBL846528 | 0.80 | KDR (0.48) | KDM4ENPC1SMN1; SMN2HSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |