SCHEMBL8460147

SCHEMBL8460147

COc1ccccc1[C@H](C)C(=O)N1CC2C(C1)C(O)(c1ccccc1OC)C(O)CC2(C)C

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 4/20 0.60
KDM4E B2RXH2 2/20 0.36
LMNA P02545 1/20 0.36
POLB P06746 1/20 0.36
HPGD P15428 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
CHRM2 P08172 1/20 0.34
CHRM4 P08173 1/20 0.34
CHRM5 P08912 1/20 0.34
CHRM1 P11229 1/20 0.34
CHRM3 P20309 1/20 0.34
ALDH1A1 P00352 3/20 0.34
GRIN2B Q13224 2/20 0.34
TSHR P16473 1/20 0.34
LPAR1 Q92633 2/20 0.33
NPY1R P25929 1/20 0.33
CYP3A4 P08684 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
OPRM1 P35372 1/20 0.33
OPRD1 P41143 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9141321 0.87 TACR1 (0.73) TACR1KDM4ELMNAPOLBHPGD
SCHEMBL8548123 0.87 TACR1 (0.73) TACR1KDM4ELMNAPOLBHPGD
SCHEMBL8894433 0.87 TACR1 (0.73) TACR1KDM4ELMNAPOLBHPGD
SCHEMBL8874393 0.82 TACR1 (0.78) TACR1KDM4ELMNAPOLBHPGD
SCHEMBL8956796 0.80 TACR1 (0.68) TACR1KDM4EALDH1A1GRIN2BTSHR
SCHEMBL8650560 0.79 TACR1 (0.59) TACR1KDM4ELMNAPOLBHPGD
SCHEMBL15678894 0.77 TACR1 (0.70) TACR1KDM4ELMNAPOLBHPGD
SCHEMBL29373653 0.76 TACR1 (0.63) TACR1KDM4ELMNAPOLBHPGD
SCHEMBL8875760 0.76 TACR1 (0.63) TACR1KDM4ELMNAPOLBHPGD
SCHEMBL8652171 0.75 TACR1 (0.73) TACR1KDM4ELMNAPOLBHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999007413-A1 SUBSTANCE P INHIBITORS IN COMBINATION WITH NMDA-BLOCKERS FOR TREATING PAIN ALGOS PHARMACEUTICAL CORPORATION (US) 1999-02-18 WO claimed
EP-0711280-B1 PERHYDROISOINDOLE DERIVATIVES AS P SUBSTANCE ANTAGONISTS RHONE POULENC RORER SA (FR) 1998-09-23 EP claimed
US-5624950-A USEFUL IN TREATMENT OF ANALGESIA, INFLAMMATION, ASTHMA, ALLERGIES, CENTRAL NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS, IMMUNE SYSTEM DISORDERS, ANTISPASMODIC AGENTS, ANTIEMETIC AGENTS RHONE-POULENC RORER S.A. (FR) 1997-04-29 US claimed
WO-1999007413-A1 SUBSTANCE P INHIBITORS IN COMBINATION WITH NMDA-BLOCKERS FOR TREATING PAIN ALGOS PHARMACEUTICAL CORPORATION (US) 1999-02-18 WO disclosed
US-5624950-A USEFUL IN TREATMENT OF ANALGESIA, INFLAMMATION, ASTHMA, ALLERGIES, CENTRAL NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS, IMMUNE SYSTEM DISORDERS, ANTISPASMODIC AGENTS, ANTIEMETIC AGENTS RHONE-POULENC RORER S.A. (FR) 1997-04-29 US disclosed