Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8461920 | 0.79 | AHR (0.36) | BRD4CREBBP | |
| Hydrochloric Acid SCHEMBL8461853 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL8459863 | 0.72 | BRD4 (0.33) | CHRNA7BRD4HRH3AURKAAURKB | |
| Hydrochloric Acid SCHEMBL8463906 | 0.66 | BRD4 (0.37) | BRD4AURKAAURKBLOXL2 | |
| Hydrochloric Acid SCHEMBL8459750 | 0.64 | AOC3 (0.47) | BRD4AURKAAURKBLOXL2 | |
| Hydrochloric Acid SCHEMBL9010009 | 0.62 | BRD4 (0.34) | BRD4AURKAAURKB | |
| Hydrochloric Acid SCHEMBL8462828 | 0.60 | CYP2A6 (0.43) | BRD4LOXL2 | |
| Hydrochloric Acid SCHEMBL8462825 | 0.58 | AOC3 (0.32) | — | |
| Hydrochloric Acid SCHEMBL8463413 | 0.57 | KDM4E (0.36) | BRD4LOXL2HRH4 | |
| 2-Methylindole SCHEMBL12420 | 0.56 | BRD4 (0.57) | BRD4AURKAAURKBLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741145-B1 | Olefin polymerization catalyst and process for producing polyolefin using the same | SUMITOMO CHEMICAL CO (JP) | 1999-12-29 | — | — | EP | disclosed |
| EP-0741145-A1 | Olefin polymerization catalyst and process for producing polyolefin using the same | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1996-11-06 | — | — | EP | disclosed |