Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.61 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846437 | 0.93 | KDR (0.58) | KDRTMPRSS4TRPV1POLB | |
| SCHEMBL846825 | 0.86 | KDR (0.60) | KDRTMPRSS4TRPV1POLBRAB9A | |
| SCHEMBL847105 | 0.83 | TRPV1 (0.73) | KDRTRPV1RAB9AKDM4ENPC1 | |
| SCHEMBL846865 | 0.83 | KDR (0.62) | KDRTMPRSS4TRPV1POLBRAB9A | |
| SCHEMBL847429 | 0.81 | KDR (0.65) | KDRTRPV1RAB9AKDM4ENPC1 | |
| SCHEMBL846740 | 0.81 | TRPV1 (0.72) | KDRTMPRSS4TRPV1POLBRAB9A | |
| SCHEMBL845816 | 0.81 | KDR (0.56) | KDRTMPRSS4TRPV1POLBRAB9A | |
| SCHEMBL846608 | 0.80 | KDR (0.65) | KDRTMPRSS4TRPV1RAB9ATSHR | |
| SCHEMBL13544521 | 0.79 | TRPV1 (0.71) | KDRTMPRSS4TRPV1RAB9ATSHR | |
| SCHEMBL846237 | 0.79 | TRPV1 (0.74) | KDRTMPRSS4TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |