Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.60 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846029 | 0.86 | KDR (0.61) | KDRTMPRSS4POLBRAB9ANPC1 | |
| SCHEMBL846865 | 0.86 | KDR (0.62) | KDRTMPRSS4POLBRAB9ANPC1 | |
| SCHEMBL846437 | 0.84 | KDR (0.58) | KDRTMPRSS4POLBTRPV1 | |
| SCHEMBL845816 | 0.80 | KDR (0.56) | KDRTMPRSS4POLBRAB9ANPC1 | |
| SCHEMBL846826 | 0.80 | KDR (0.58) | KDRTMPRSS4RAB9ANPC1KDM4E | |
| SCHEMBL846608 | 0.79 | KDR (0.65) | KDRTMPRSS4RAB9ANPC1KDM4E | |
| SCHEMBL13544521 | 0.78 | TRPV1 (0.71) | KDRTMPRSS4RAB9ANPC1KDM4E | |
| SCHEMBL845644 | 0.76 | TRPV1 (0.72) | KDRTMPRSS4RAB9ANPC1KDM4E | |
| SCHEMBL846740 | 0.76 | TRPV1 (0.72) | KDRTMPRSS4POLBRAB9AKDM4E | |
| SCHEMBL29432941 | 0.75 | RAB9A (0.62) | KDRPOLBRAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |