Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 10/20 | 0.47 |
| ▸ | RXRA | P19793 | 6/20 | 0.46 |
| ▸ | RXRB | P28702 | 5/20 | 0.46 |
| ▸ | RXRG | P48443 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8461788 | 0.86 | PSEN1 (0.48) | PSEN1RXRARXRBRXRG | |
| SCHEMBL8308667 | 0.86 | PSEN1 (0.45) | PSEN1POLB | |
| SCHEMBL8457574 | 0.83 | PSEN1 (0.45) | PSEN1RXRARXRBRXRG | |
| SCHEMBL5957804 | 0.82 | PSEN1 (0.40) | PSEN1 | |
| SCHEMBL7796530 | 0.80 | PSEN1 (0.41) | PSEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6597291 | 0.78 | PSEN1 (0.65) | PSEN1 | |
| SCHEMBL4592776 | 0.78 | PSEN1 (0.65) | PSEN1 | |
| SCHEMBL10074171 | 0.78 | PSEN1 (0.60) | PSEN1 | |
| SCHEMBL10547297 | 0.76 | PSEN1 (0.48) | PSEN1 | |
| SCHEMBL10536937 | 0.76 | PSEN1 (0.48) | PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |