SCHEMBL6597291

SCHEMBL6597291

Cc1c(C)c2c(c(C)c1OCc1ccccc1)CCC(C)(C(=O)O)O2

nearest known ligand 0.65

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PSEN1 P49768 12/20 0.65
PTGS1 P23219 1/20 0.56
PTGS2 P35354 1/20 0.56
CYP1A2 P05177 1/20 0.56
CYP3A4 P08684 1/20 0.56
TSHR P16473 1/20 0.56
TTPA P49638 3/20 0.41
ALOX5 P09917 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4592776 1.00 PSEN1 (0.65) PSEN1PTGS1PTGS2CYP1A2CYP3A4
SCHEMBL2140140 0.90 PSEN1 (0.53) PSEN1PTGS1PTGS2CYP1A2CYP3A4
SCHEMBL11701054 0.90 PSEN1 (0.56) PSEN1PTGS1PTGS2CYP1A2CYP3A4
SCHEMBL2140130 0.90 PSEN1 (0.53) PSEN1PTGS1PTGS2CYP1A2CYP3A4
SCHEMBL6724988 0.88 PSEN1 (0.58) PSEN1PTGS1PTGS2CYP1A2CYP3A4
SCHEMBL6732328 0.86 PSEN1 (0.60) PSEN1PTGS1PTGS2CYP1A2CYP3A4
SCHEMBL7999828 0.84 PSEN1 (0.46) PSEN1PTGS1PTGS2CYP1A2CYP3A4
SCHEMBL10536937 0.84 PSEN1 (0.48) PSEN1ALOX5
SCHEMBL10547297 0.84 PSEN1 (0.48) PSEN1ALOX5
SCHEMBL10547295 0.84 PSEN1 (0.48) PSEN1ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240400529-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA STEALTH BIOTHERAPEUTICS INC. (US) 2024-12-05 US disclosed
US-20240368098-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA STEALTH BIOTHERAPEUTICS INC. (US) 2024-11-07 US disclosed
US-20240293339-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA Stealth Bio Therapeutics Inc. (US) 2024-09-05 US disclosed
US-12049455-B2 Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia STEALTH BIOTHERAPEUTICS INC. (US) 2024-07-30 US disclosed
EP-4351547-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA Stealth BioTherapeutics Inc. (US) 2024-04-17 EP disclosed
US-20230303506-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA STEALTH BIOTHERAPEUTICS INC. (US) 2023-09-28 US disclosed
US-20230303506-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA STEALTH BIOTHERAPEUTICS INC. (US) 2023-09-28 US disclosed
US-11584728-B2 Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia STEALTH BIOTHERAPEUTICS INC. (US) 2023-02-21 US disclosed
US-11584728-B2 Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia STEALTH BIOTHERAPEUTICS INC. (US) 2023-02-21 US disclosed
WO-2022261347-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA STEALTH BIOTHERAPEUTICS INC. (US) 2022-12-15 WO disclosed
EP-1214309-B8 PREPARING AMIDINES DERIVED FROM 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID SOD CONSEILS RECH APPLIC (FR) 2004-07-14 EP disclosed
EP-1214309-B1 PREPARING AMIDINES DERIVED FROM 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID SCRAS (FR) 2004-03-10 EP disclosed
US-6653472-B1 Catalytic reduction of 3,4-dihydro-6-benzyloxy-2, 5,7,8-tetramethyl-2-(4-((4-nitrophenyl)-1-piperazinyl)-carbony l) -2H-1-benzopyrane. SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2003-11-25 US disclosed
EP-1214309-A1 PREPARING AMIDINES DERIVED FROM 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID S.C.R.A.S. (FR) 2002-06-19 EP disclosed
WO-2001017987-A1 PREPARING AMIDINES DERIVED FROM 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID S.C.R.A.S. (FR) 2001-03-15 WO disclosed
US-6200990-B1 4-PHENYLPIPERIDIN-1-YLETHANOL DERIVATIVES; VISION DEFECTS, BRAIN AND SPINAL CORD INJURIES ALCON LABORATORIES, INC. 2001-03-13 US disclosed
US-4026907-A INTERMEDIATES FOR ALPHA-TOCOPHEROL HOFFMANN-LA ROCHE INC. (US) 1977-05-31 US disclosed
US-4018799-A INTERMEDIATES FOR TOCOPHEROL HOFFMANN-LA ROCHE INC. (US) 1977-04-19 US disclosed
US-4003919-A INTERMEDIATES FOR ALPHA-TOCOPHEROL HOFFMANN-LA ROCHE INC. (US) 1977-01-18 US disclosed
US-3947473-A (6-HYDROXY-CHROMAN-2-YL) CARBOXYLIC ACID DERIVATIVES HOFFMAN-LA ROCHE INC. (US) 1976-03-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240293339-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA AIFM2, FH, FECH PSEN1 168/4885PTGS1 332/4885PTGS2 455/4885
US-20230303506-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA FH, COQ8A, TFAM PSEN1 285/4885PTGS1 682/4885PTGS2 1030/4885
US-11584728-B2 Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia FH, COQ8A, TFAM PSEN1 285/4885PTGS1 682/4885PTGS2 1030/4885
US-20240400529-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA FH, COQ8A, TFAM PSEN1 285/4885PTGS1 682/4885PTGS2 1030/4885
US-12049455-B2 Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia FH, COQ8A, TFAM PSEN1 285/4885PTGS1 682/4885PTGS2 1030/4885
US-20240368098-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA FH, COQ8A, TFAM PSEN1 285/4885PTGS1 682/4885PTGS2 1030/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.