Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 12/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | TTPA | P49638 | 3/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6597291 | 1.00 | PSEN1 (0.65) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL2140140 | 0.90 | PSEN1 (0.53) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL11701054 | 0.90 | PSEN1 (0.56) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL2140130 | 0.90 | PSEN1 (0.53) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL6724988 | 0.88 | PSEN1 (0.58) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL6732328 | 0.86 | PSEN1 (0.60) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL7999828 | 0.84 | PSEN1 (0.46) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL10536937 | 0.84 | PSEN1 (0.48) | PSEN1ALOX5 | |
| SCHEMBL10547297 | 0.84 | PSEN1 (0.48) | PSEN1ALOX5 | |
| SCHEMBL10547295 | 0.84 | PSEN1 (0.48) | PSEN1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254130-B1 | TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF | RES DEV FOUNDATION (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1254130-A4 | TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF | RES DEV FOUNDATION (US) | 2003-04-23 | — | — | EP | disclosed |
| EP-1254130-A1 | TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF | RESEARCH DEVELOPMENT FOUNDATION (US) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001058889-A1 | TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF | RESEARCH DEVELOPMENT FOUNDATION (US) | 2001-08-16 | — | — | WO | disclosed |