Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 5/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 9/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29726741 | 0.83 | NR1H4 (0.54) | SERPINE1PPARGNR1H4EPHX2NPC1 | |
| SCHEMBL10762782 | 0.82 | CYP2C9 (0.50) | CYP2C9SERPINE1PPARGNR1H4EPHX2 | |
| SCHEMBL7223016 | 0.79 | CYP2C9 (0.50) | CYP2C9NR1H4EPHX2NPC1ALDH1A1 | |
| SCHEMBL6109346 | 0.79 | SERPINE1 (0.77) | SERPINE1PPARGNR1H4NPC1ALDH1A1 | |
| SCHEMBL555886 | 0.77 | CYP2C9 (0.53) | CYP2C9SERPINE1PPARGNR1H4NPC1 | |
| SCHEMBL12593904 | 0.76 | NPC1 (0.68) | CYP2C9SERPINE1PPARGNR1H4NPC1 | |
| SCHEMBL8461876 | 0.76 | HDAC3 (0.63) | NR1H4EPHX2NPC1RAB9ASRD5A2 | |
| SCHEMBL8458778 | 0.76 | HDAC8 (0.78) | PPARGNR1H4EPHX2NPC1ALDH1A1 | |
| SCHEMBL6107043 | 0.76 | PPARG (0.64) | SERPINE1PPARGNR1H4NPC1TDP1 | |
| SCHEMBL7297239 | 0.76 | NR1H4 (0.81) | NR1H4EPHX2NPC1RAB9ASRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |