Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | RXRA | P19793 | 3/20 | 0.55 |
| ▸ | RXRB | P28702 | 3/20 | 0.55 |
| ▸ | RXRG | P48443 | 1/20 | 0.55 |
| ▸ | PPARA | Q07869 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17296531 | 0.88 | CA1 (0.56) | NR1H4EPHX2CA1CA2RXRA | |
| SCHEMBL8461643 | 0.86 | CA1 (0.74) | NR1H4EPHX2CA1CA2RXRA | |
| SCHEMBL8460674 | 0.84 | NR1H4 (0.58) | NR1H4EPHX2CA1CA2RXRA | |
| SCHEMBL29015814 | 0.81 | MEN1 (0.54) | CA1CA2ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL4418236 | 0.78 | CA1 (0.59) | CA1CA2ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL8461599 | 0.77 | NR1H4 (0.58) | NR1H4EPHX2CA1CA2RXRA | |
| SCHEMBL8461876 | 0.76 | HDAC3 (0.63) | NR1H4EPHX2RXRARXRBRXRG | |
| SCHEMBL8460876 | 0.75 | CA1 (0.63) | NR1H4EPHX2CA1CA2RXRA | |
| SCHEMBL20236127 | 0.75 | PPARA (0.62) | PPARAKMT2ANR4A2SRD5A2MAPT | |
| SCHEMBL5211384 | 0.75 | ALDH1A1 (0.65) | NR1H4EPHX2CA1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |