⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL996217 | 0.86 | — | — | |
| SCHEMBL14274191 | 0.83 | PYGB (0.46) | — | |
| SCHEMBL20692159 | 0.83 | PYGB (0.46) | — | |
| SCHEMBL14465071 | 0.83 | PYGB (0.46) | — | |
| SCHEMBL5019779 | 0.83 | PYGB (0.46) | — | |
| SCHEMBL15343514 | 0.83 | PYGB (0.46) | — | |
| SCHEMBL19255671 | 0.81 | PYGB (0.49) | — | |
| SCHEMBL14306795 | 0.81 | PYGB (0.49) | — | |
| SCHEMBL13768389 | 0.81 | PYGB (0.49) | — | |
| SCHEMBL26210669 | 0.81 | PYGB (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143396-B2 | 1-[2′, 3′ -dideoxy-3′ C- (hydroxymethyl)—beta-D-erythro-pentofuranosyl] cytosine derivatives as HIV inhibitors | MEDIVIR AB (SE) | 2012-03-27 | — | — | US | disclosed |
| US-20110112294-A1 | 1-[2', 3' -DIDEOXY-3' C- (HYDROXYMETHYL) - BETA-D-ERYTHRO-PENTOFURANOSYL] CYTOSINE DERIVATIVES AS HIV INHIBITORS | MEDIVIR AB (SE) | 2011-05-12 | — | — | US | disclosed |
| US-7888367-B2 | reverse transcriptase mutants which allow an obligate chain terminating nucleoside- or nucleotide phosphate to be excised from the nascent DNA strand by ATP- or pyrophosphate-mediated excision | MEDIVIR AB (SE) | 2011-02-15 | — | — | US | disclosed |
| US-20080221140-A1 | 1-[2',3' -Dideoxy-3' C-(Hydroxymethyl) - Beta-D-Erythro-Pentofuranosyl] Cytosine Derivatives as Hiv | MEDIVIR AB (SE) | 2008-09-11 | — | — | US | disclosed |