Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846230 | 1.00 | MAPT (0.56) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL846056 | 0.82 | BCHE (0.52) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL846183 | 0.80 | MAPT (0.58) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL846184 | 0.80 | MAPT (0.58) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL846660 | 0.79 | NPC1 (0.56) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL846661 | 0.79 | NPC1 (0.56) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL846143 | 0.78 | MAPT (0.62) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL846144 | 0.78 | MAPT (0.62) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL846918 | 0.76 | RAB9A (0.44) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL846919 | 0.76 | RAB9A (0.44) | MAPTNPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |