Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 4/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8462469 | 1.00 | LTB4R (0.49) | LTB4RPDE10AALOX5APCYSLTR1GPBAR1 | |
| SCHEMBL8462463 | 1.00 | LTB4R (0.49) | LTB4RPDE10AALOX5APCYSLTR1GPBAR1 | |
| SCHEMBL8029124 | 0.83 | GPBAR1 (0.49) | PDE10ACYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL8032678 | 0.83 | GPBAR1 (0.49) | PDE10ACYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL8032680 | 0.83 | GPBAR1 (0.49) | PDE10ACYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL8461158 | 0.79 | CYSLTR1 (0.49) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL8461154 | 0.79 | CYSLTR1 (0.49) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL8461147 | 0.79 | CYSLTR1 (0.49) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL8032722 | 0.76 | CYSLTR1 (0.49) | PDE10AALOX5APCYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL8029321 | 0.76 | GPBAR1 (0.53) | PDE10AALOX5APCYSLTR1GPBAR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |