SCHEMBL8463275

SCHEMBL8463275

O=Ic1c(C(=O)O)ccc(C(=O)O)c1I

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.42
ALDH1A1 P00352 5/20 0.37
ALOX15 P16050 1/20 0.37
SELL P14151 1/20 0.35
SELP P16109 1/20 0.35
TSHR P16473 2/20 0.34
CA12 O43570 2/20 0.34
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
CA7 P43166 2/20 0.34
CA9 Q16790 2/20 0.34
CA14 Q9ULX7 2/20 0.34
PTPN1 P18031 2/20 0.34
PTPRC P08575 1/20 0.34
PTPN2 P17706 1/20 0.34
PTPRA P18433 1/20 0.34
PTPRB P23467 1/20 0.34
PTPRE P23469 1/20 0.34
PTPN6 P29350 1/20 0.34
TPMT P51580 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3808402 0.78 CYP1A2 (0.58) CYP1A2ALDH1A1ALOX15SELLSELP
SCHEMBL8461201 0.75 ALDH1A1 (0.44) ALDH1A1ALOX15TSHRCA12CA1
SCHEMBL8460824 0.75 ALDH1A1 (0.55) CYP1A2ALDH1A1ALOX15TSHRCA12
SCHEMBL8461032 0.72 TSHR (0.38) TSHRPTPN1PTPRCPTPN2PTPRA
SCHEMBL8461066 0.71 GPR35 (0.50) CYP1A2ALDH1A1PTPN1MAPTKDM4E
SCHEMBL8463512 0.71 PTPRC (0.43) CYP1A2ALDH1A1ALOX15TSHRCA12
SCHEMBL8462239 0.71 CYP1A2 (0.39) CYP1A2ALDH1A1ALOX15SELLSELP
SCHEMBL625273 0.70 CYP1A2 (0.48) CYP1A2ALDH1A1ALOX15SELLSELP
SCHEMBL2443197 0.69 ALDH1A1 (0.60) CYP1A2ALDH1A1ALOX15TSHRCA12
SCHEMBL23600929 0.68 SELL (0.54) CYP1A2ALDH1A1ALOX15SELLSELP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0745326-B1 Stabilization of aqueous 3-isothiazolone solutions ROHM & HAAS (US) 1999-09-22 EP disclosed
US-5594017-A WITH AN IODOSYL OR IODYL COMPOUND ROHM AND HAAS COMPANY (US) 1997-01-14 US disclosed
EP-0745326-A1 Stabilization of aqueous 3-isothiazolone solutions ROHM AND HAAS COMPANY (US) 1996-12-04 EP disclosed