SCHEMBL8463553

SCHEMBL8463553

Fc1c(I)ccc(-c2ccccc2)c1F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 2/20 0.44
FEN1 P39748 2/20 0.44
BACE1 P56817 1/20 0.36
ALOX5 P09917 1/20 0.35
ALDH1A1 P00352 4/20 0.35
HSD17B10 Q99714 2/20 0.34
HPGD P15428 2/20 0.34
BCL2L1 Q07817 1/20 0.34
CYP2A6 P11509 1/20 0.34
MAPK1 P28482 1/20 0.34
MAPT P10636 2/20 0.34
PTGS1 P23219 3/20 0.33
MEN1 O00255 2/20 0.33
PTGS2 P35354 2/20 0.33
KMT2A Q03164 2/20 0.33
FABP2 P12104 1/20 0.33
TSHR P16473 1/20 0.33
AKR1C4 P17516 1/20 0.33
ADRA2B P18089 1/20 0.33
CHRM3 P20309 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10533047 0.85 ALOX5AP (0.53) ALOX5APFEN1BACE1ALOX5ALDH1A1
SCHEMBL7610038 0.82 ALDH1A1 (0.39) ALOX5APFEN1BACE1ALDH1A1HSD17B10
SCHEMBL19308566 0.80 ALDH1A1 (0.50) ALOX5APFEN1BACE1ALOX5ALDH1A1
SCHEMBL14648803 0.78 PTGS2 (0.39) PTGS1MEN1PTGS2KMT2AAKR1C3
SCHEMBL10000685 0.78 ESR1 (0.40) HSD17B10BCL2L1CYP2C9CYP2C19ESR2
SCHEMBL17859609 0.77 PTGS2 (0.38) PTGS1PTGS2
SCHEMBL421377 0.77 ALDH1A1 (0.41) ALDH1A1HSD17B10HPGDMAPK1MEN1
SCHEMBL1685615 0.76 ALOX5AP (0.47) ALOX5APFEN1BACE1ALOX5ALDH1A1
SCHEMBL16089556 0.76 ALOX5AP (0.40) ALOX5APFEN1BACE1ALOX5ALDH1A1
SCHEMBL10028790 0.75 PTGS1 (0.41) PTGS1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107021883-B Synthetic method and application of polysubstituted biphenyl halide liquid crystal intermediate HEBEI MAISON CHEMICAL CO., LTD. (CN) 2019-12-10 CN disclosed
EP-0934237-A1 TETRACYCLIC COMPOUND HAVING LATERAL HALOGEN SUBSTITUENT AND LIQUID CRYSTAL COMPOSITION COMPRISING THE SAME CHISSO CORPORATION (JP) 1999-08-11 EP disclosed
WO-1998008792-A1 TETRACYCLIC COMPOUND HAVING LATERAL HALOGEN SUBSTITUENT AND LIQUID CRYSTAL COMPOSITION COMPRISING THE SAME CHISSO CORPORATION (JP) 1998-03-05 WO disclosed