SCHEMBL8463554

SCHEMBL8463554

Cc1cc(O[Si](C)(C)C)ccc1O[Si](C)(C)C

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.32
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA7 P43166 1/20 0.32
CA9 Q16790 1/20 0.32
CA14 Q9ULX7 1/20 0.32
KDM4E B2RXH2 2/20 0.30
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2D6 P10635 1/20 0.30
CYP2C19 P33261 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
TSHR P16473 1/20 0.30
NQO2 P16083 1/20 0.30
HAO1 Q9UJM8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11381637 0.82 HAO1 (0.43) MAPTL3MBTL1HAO1
SCHEMBL13527784 0.80 L3MBTL1 (0.45) MAPTCA1CA2CA9CYP3A4
SCHEMBL13318435 0.77 TP53 (0.46) MAPTKDM4ECYP1A2CYP3A4CYP2D6
SCHEMBL4859174 0.77 STS (0.37) MAPT
SCHEMBL10392636 0.77 CYP3A4 (0.46) MAPTKDM4ECYP3A4L3MBTL1TSHR
SCHEMBL6763269 0.76 CA12 (0.47) CA12CA1CA9NQO2
SCHEMBL12758265 0.76 NQO2 (0.32) MAPTNQO2
SCHEMBL24119821 0.74 MAPT (0.37) MAPTCA12CA1CA9KDM4E
SCHEMBL7982954 0.74 ALDH1A1 (0.41) CA12CA1CA2CA9CYP3A4
SCHEMBL4763549 0.72 CA1 (0.39) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0909301-A1 BIODEGRADABLE LIQUID CRYSTALLINE POLYMERS Smith & Nephew plc (GB) 1999-04-21 EP disclosed
WO-1997048782-A1 BIODEGRADABLE LIQUID CRYSTALLINE POLYMERS SMITH & NEPHEW PLC (GB) 1997-12-24 WO disclosed