Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8459555 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL8462825 | 0.69 | AOC3 (0.32) | AOC3CA2NPC1RAB9AGSK3B | |
| Hydrochloric Acid SCHEMBL8462951 | 0.64 | AOC3 (0.47) | CYP2A6AOC3BRD4CA2NPC1 | |
| Hydrochloric Acid SCHEMBL8459502 | 0.63 | KDM4E (0.36) | CYP2A6AOC3BRD4CA2NPC1 | |
| Hydrochloric Acid SCHEMBL8463556 | 0.60 | AOC3 (0.42) | CYP2A6AOC3BRD4CA2NPC1 | |
| Hydrochloric Acid SCHEMBL8459779 | 0.60 | CYP2A6 (0.37) | CYP2A6AOC3BRD4CA2NPC1 | |
| Hydrochloric Acid SCHEMBL6257336 | 0.57 | AOC3 (0.52) | CYP2A6AOC3BRD4CA2NPC1 | |
| Hydrochloric Acid SCHEMBL30577223 | 0.57 | AOC3 (0.52) | CYP2A6AOC3BRD4CA2NPC1 | |
| Hydrochloric Acid SCHEMBL30028208 | 0.57 | AOC3 (0.52) | CYP2A6AOC3BRD4CA2NPC1 | |
| SCHEMBL28840867 | 0.56 | CA12 (0.46) | CYP2A6AOC3BRD4CA2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741145-B1 | Olefin polymerization catalyst and process for producing polyolefin using the same | SUMITOMO CHEMICAL CO (JP) | 1999-12-29 | — | — | EP | disclosed |
| EP-0741145-A1 | Olefin polymerization catalyst and process for producing polyolefin using the same | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1996-11-06 | — | — | EP | disclosed |