Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.54 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8462441 | 0.88 | CYP19A1 (0.65) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8466308 | 0.87 | CYP19A1 (0.63) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8463991 | 0.84 | MAOB (0.65) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8465206 | 0.82 | MAOB (0.53) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8465989 | 0.80 | CYP3A4 (0.64) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8465133 | 0.80 | CYP19A1 (0.55) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8888991 | 0.80 | CYP3A4 (0.58) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8464540 | 0.76 | CYP3A4 (0.49) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16264014 | 0.76 | CYP3A4 (0.72) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28259502 | 0.74 | MAOB (0.72) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0313295-B1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |