Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.54 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8462441 | 0.92 | CYP19A1 (0.65) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9323920 | 0.83 | MAOB (0.49) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8461403 | 0.83 | MAOB (0.52) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6822323 | 0.80 | CYP19A1 (0.76) | CYP19A1PDE4D | |
| SCHEMBL8465134 | 0.80 | CYP3A4 (0.57) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8466153 | 0.79 | LTB4R (0.67) | — | |
| SCHEMBL9324238 | 0.79 | LTB4R (0.68) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| Deoxysappanone B Trimethyl Ether SCHEMBL4736096 | 0.78 | CYP3A4 (1.00) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5857661 | 0.78 | CYP19A1 (0.85) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| Deoxysappanone B Trimethyl Ether SCHEMBL29903817 | 0.78 | CYP3A4 (1.00) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| US-5298512-A | Substituted chromans and their use in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1994-03-29 | — | — | US | disclosed |
| EP-0391625-B1 | Substituted chromans in the treatment of asthma, arthritis and related diseases | PFIZER (US) | 1994-01-26 | — | — | EP | disclosed |
| EP-0313295-B1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| WO-1990012010-A1 | SUBSTITUTED CHROMANS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1990-10-18 | — | — | WO | disclosed |
| EP-0391625-A1 | Substituted chromans in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1990-10-10 | — | — | EP | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |