Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8465230 | 1.00 | ESR1 (0.41) | ESR1ESR2DRD1DRD2HTR2A | |
| SCHEMBL8465226 | 1.00 | ESR1 (0.41) | ESR1ESR2DRD1DRD2HTR2A | |
| SCHEMBL8465149 | 0.83 | KDM1A (0.50) | HTR2A | |
| SCHEMBL8465154 | 0.83 | KDM1A (0.50) | HTR2A | |
| SCHEMBL8464032 | 0.77 | DRD3 (0.38) | ESR1ESR2DRD2GRIN1GRIN2B | |
| SCHEMBL8464035 | 0.77 | DRD3 (0.38) | ESR1ESR2DRD2GRIN1GRIN2B | |
| SCHEMBL8464040 | 0.77 | DRD3 (0.38) | ESR1ESR2DRD2GRIN1GRIN2B | |
| SCHEMBL8466002 | 0.74 | CYSLTR1 (0.54) | — | |
| SCHEMBL8348051 | 0.74 | ALOX5 (0.38) | — | |
| SCHEMBL8348060 | 0.74 | ALOX5 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |