Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | SNRNP200 | O75643 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8464064 | 0.83 | CYSLTR1 (0.49) | — | |
| SCHEMBL8465611 | 0.82 | MAOB (0.55) | CYP19A1BRD4CREBBPMAOAMAOB | |
| SCHEMBL7784427 | 0.78 | CYP19A1 (0.62) | CYP19A1ACHE | |
| SCHEMBL30667087 | 0.78 | CYP19A1 (0.62) | CYP19A1ACHE | |
| SCHEMBL8029113 | 0.74 | THRA (0.45) | PDE4DCYP19A1ACHEBRD4CREBBP | |
| SCHEMBL8466193 | 0.74 | CYP19A1 (0.60) | CYP19A1ACHEMAOB | |
| SCHEMBL8461347 | 0.74 | CYP19A1 (0.52) | CYP19A1 | |
| SCHEMBL8465850 | 0.73 | LTB4R (0.43) | BRD4CREBBPMAOAMAOBKDM4E | |
| SCHEMBL8465852 | 0.73 | LTB4R (0.43) | BRD4CREBBPMAOAMAOBKDM4E | |
| SCHEMBL15484711 | 0.73 | CYP19A1 (0.62) | PDE4DCYP19A1ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0313295-B1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |