Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6424185 | 0.87 | TP53 (0.61) | TP53MEN1KMT2ATSHRHPGD | |
| SCHEMBL6998975 | 0.81 | TP53 (0.63) | TP53MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL8702905 | 0.80 | TP53 (0.61) | TP53MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL6998971 | 0.78 | TP53 (0.59) | TP53MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL8530663 | 0.76 | HPGD (0.54) | MEN1KMT2ATSHRHPGDLMNA | |
| SCHEMBL6989737 | 0.76 | TP53 (0.56) | TP53MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL8125656 | 0.76 | ALDH1A1 (0.58) | TP53MEN1KMT2ATSHRHPGD | |
| SCHEMBL6425207 | 0.76 | KMT2A (0.52) | TP53MEN1KMT2ATSHRHPGD | |
| SCHEMBL8134305 | 0.75 | TP53 (0.52) | TP53MEN1KMT2ATSHRHPGD | |
| SCHEMBL6421265 | 0.74 | KMT2A (0.51) | TP53MEN1KMT2ATSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920425-A1 | SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1999-06-09 | — | — | EP | disclosed |
| WO-1997019074-A1 | SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1997-05-29 | — | — | WO | disclosed |