Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20449071 | 0.80 | TDP1 (0.58) | TDP1ALDH1A1LMNACYP3A4THRB | |
| SCHEMBL23676916 | 0.80 | TDP1 (0.58) | TDP1ALDH1A1LMNACYP3A4THRB | |
| SCHEMBL841689 | 0.79 | TDP1 (0.70) | TDP1ALDH1A1LMNACYP3A4THRB | |
| SCHEMBL16603000 | 0.78 | DPP4 (0.56) | DPP4TDP1ALDH1A1LMNACYP3A4 | |
| SCHEMBL13323693 | 0.78 | ADRA2C (0.57) | DPP4TDP1ALDH1A1LMNACYP3A4 | |
| SCHEMBL4304681 | 0.75 | ADRA2C (0.64) | TDP1ALDH1A1LMNACYP3A4THRB | |
| SCHEMBL22502960 | 0.75 | TDP1 (0.64) | TDP1ALDH1A1LMNACYP3A4THRB | |
| SCHEMBL2255556 | 0.75 | TDP1 (0.64) | TDP1ALDH1A1LMNACYP3A4THRB | |
| SCHEMBL1061133 | 0.75 | TDP1 (0.64) | TDP1ALDH1A1LMNACYP3A4THRB | |
| SCHEMBL5604987 | 0.73 | GAA (0.73) | TDP1ALDH1A1LMNACYP3A4THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922722-A | PIPERIDINE OR PIPERAZINE DERIVATIVES TO TREAT BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. (US) | 1999-07-13 | — | — | US | disclosed |
| EP-0865280-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5807856-A | Alpha 1a adrenergic receptor antagonist | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | disclosed |
| WO-1997017967-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-05-22 | — | — | WO | disclosed |
| WO-1997018209-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-05-22 | — | — | WO | disclosed |