Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.54 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.54 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8466002 | 1.00 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5AP | |
| SCHEMBL8462779 | 0.84 | LTB4R (0.59) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5 | |
| SCHEMBL8463992 | 0.84 | LTB4R (0.59) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5 | |
| SCHEMBL8466275 | 0.83 | LTB4R (0.58) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5AP | |
| SCHEMBL8462851 | 0.83 | LTB4R (0.58) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5AP | |
| SCHEMBL8348060 | 0.82 | ALOX5 (0.38) | CYSLTR1CYSLTR2ALOX5APALOX5 | |
| SCHEMBL8348055 | 0.82 | ALOX5 (0.38) | CYSLTR1CYSLTR2ALOX5APALOX5 | |
| SCHEMBL8348051 | 0.82 | ALOX5 (0.38) | CYSLTR1CYSLTR2ALOX5APALOX5 | |
| Hydrochloric Acid SCHEMBL8465772 | 0.82 | LTB4R (0.57) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5AP | |
| Hydrochloric Acid SCHEMBL8465778 | 0.82 | LTB4R (0.57) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |