Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30454517 | 0.84 | SIGMAR1 (0.38) | SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL8469341 | 0.84 | SIGMAR1 (0.38) | SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL736446 | 0.79 | — | — | |
| SCHEMBL22123483 | 0.78 | ROCK2 (0.36) | AAK1 | |
| SCHEMBL10919639 | 0.77 | — | — | |
| SCHEMBL846505 | 0.70 | PARP1 (0.39) | — | |
| SCHEMBL6789771 | 0.70 | PARP1 (0.39) | — | |
| SCHEMBL15902739 | 0.70 | PARP1 (0.39) | — | |
| Hydrochloric Acid SCHEMBL9670228 | 0.68 | PARP1 (0.42) | — | |
| SCHEMBL4624876 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10059671-B2 | Positive allosteric modulators of mGluR3 | PREXTON THERAPEUTICS SA (CH) | 2018-08-28 | — | — | US | disclosed |
| US-20150361046-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR3 | MERCK PATENT GMBH (DE) | 2015-12-17 | — | — | US | disclosed |
| EP-2951157-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR3 | Merck Patent GmbH (DE) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014117919-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR3 | MERCK PATENT GMBH (DE) | 2014-08-07 | — | — | WO | disclosed |
| CN-102850375-A | Polysubstituted pyridine[4,5-d]oxazine compounds and preparation method | UNIV JIANGXI NORMAL | 2013-01-02 | — | — | CN | disclosed |
| CN-102850375-A | Polysubstituted pyridine[4,5-d]oxazine compounds and preparation method | UNIV JIANGXI NORMAL | 2013-01-02 | — | — | CN | disclosed |
| EP-0915879-A1 | NOVEL COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998001449-A1 | NOVEL COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-01-15 | — | — | WO | disclosed |
| EP-0327239-B1 | 1-carbacephalosporin antibiotics | LILLY CO ELI (US) | 1994-06-22 | — | — | EP | disclosed |
| US-5011938-A | Antimicrobials | ELI LILLY AND COMPANY (US) | 1991-04-30 | — | — | US | disclosed |
| US-4940718-A | BACTERICIDES | ELI LILLY AND COMPANY (US) | 1990-07-10 | — | — | US | disclosed |
| US-4902707-A | Bicyclic pyrazolidinones, compositions and use | ELI LILLY AND COMPANY (US) | 1990-02-20 | — | — | US | disclosed |
| EP-0327239-A1 | 1-carbacephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1989-08-09 | — | — | EP | disclosed |
| EP-0203722-A1 | Bicyclic pyrazolidinones | ELI LILLY AND COMPANY (US) | 1986-12-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150361046-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR3 | GRM3, GRM1, GRM4 | SIGMAR1 302/4885CHRNB2 170/4885CHRNA4 44/4885 |
| US-10059671-B2 | Positive allosteric modulators of mGluR3 | GRM3, GRM1, GRM4 | SIGMAR1 302/4885CHRNB2 170/4885CHRNA4 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.