Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11857334 | 0.81 | ALDH1A1 (0.44) | ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL5593717 | 0.78 | KDM4E (0.56) | ALDH1A1GAA | |
| SCHEMBL598525 | 0.77 | TSHR (0.56) | ALDH1A1MAPTL3MBTL1GAA | |
| SCHEMBL31285728 | 0.75 | KDM4E (0.49) | — | |
| SCHEMBL19376943 | 0.74 | TAAR1 (0.46) | TAAR1 | |
| SCHEMBL31285559 | 0.73 | KDM4E (0.55) | ALDH1A1GAAMAOB | |
| SCHEMBL12272460 | 0.73 | TSHR (0.51) | ALDH1A1MAPTL3MBTL1GAA | |
| SCHEMBL6398658 | 0.72 | SLC18A3 (0.50) | — | |
| SCHEMBL6977367 | 0.72 | CTSD (0.41) | — | |
| SCHEMBL11159707 | 0.72 | MAPT (0.49) | ALDH1A1MAPTL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682662-B1 | BICYCLIC CARBOXYLIC ACID LEUKOTRIENE B4 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 1999-08-18 | — | — | EP | disclosed |
| EP-0682662-A1 | BICYCLIC CARBOXYLIC ACID LEUKOTRIENE B 4? ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-11-22 | — | — | EP | disclosed |
| US-5457124-A | Antiinflammatory agent | HOFFMANN-LA ROCHE INC. (US) | 1995-10-10 | — | — | US | disclosed |
| WO-1995015956-A1 | BICYCLIC CARBOXYLIC ACID LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-15 | — | — | WO | disclosed |