SCHEMBL8466906

SCHEMBL8466906

COC(OC)(C(Cl)CC(=O)O)C(F)(F)F

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.30
SLC22A6 Q4U2R8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8676611 0.83 TSHR (0.33)
Bicarbonate SCHEMBL8466907 0.74
SCHEMBL9504373 0.70 SLC22A6 (0.38) ALDH1A1SLC22A6
SCHEMBL8678309 0.69
SCHEMBL1132009 0.68 SLC22A6 (0.39) SLC22A6
SCHEMBL10866600 0.65 SLC22A6 (0.41) ALDH1A1SLC22A6
SCHEMBL6460798 0.64
SCHEMBL7521295 0.64
SCHEMBL158448 0.64
SCHEMBL8466932 0.63 ALDH1A1 (0.30) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0780362-B1 3,3-Dioxy-4,4,4-trifluorobutyric acid derivatives BAYER AG (DE) 1999-10-20 EP disclosed
US-5739394-A 3,3-dioxy-4,4,4-trifluorobutyric acid derivatives BAYER AKTIENGESELLSCHAFT (DE) 1998-04-14 US disclosed
EP-0780362-A1 3,3-Dioxy-4,4,4-trifluorobutyric acid derivatives BAYER AG (DE) 1997-06-25 EP disclosed