Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 11/20 | 0.61 |
| ▸ | GGPS1 | O95749 | 8/20 | 0.61 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8778439 | 0.98 | FDPS (0.63) | FDPSGGPS1AGTR1OPRM1PDE3A | |
| Iodide SCHEMBL8468421 | 0.97 | FDPS (0.61) | FDPSGGPS1AGTR1OPRM1PDE3A | |
| SCHEMBL15452876 | 0.78 | FDPS (0.48) | FDPSGGPS1AGTR1OPRM1PDE3A | |
| Iodide SCHEMBL7859982 | 0.78 | FDPS (0.42) | FDPSGGPS1HTTDNM1 | |
| Phosphoric Acid SCHEMBL1462860 | 0.77 | HTT (0.71) | HTTDNM1 | |
| Didecyldimethylammonium SCHEMBL2311559 | 0.77 | HTT (0.71) | HTTDNM1 | |
| Phosphoric Acid SCHEMBL29166354 | 0.77 | HTT (0.71) | HTTDNM1 | |
| Phosphoric Acid SCHEMBL17529948 | 0.77 | HTT (0.71) | HTTDNM1 | |
| Phosphoric Acid SCHEMBL28622942 | 0.77 | HTT (0.71) | HTTDNM1 | |
| Phosphoric Acid SCHEMBL28624995 | 0.77 | HTT (0.71) | HTTDNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869471-A | Methods for the treatment of arthritis using phosphonates and NSAIDS | THE PROCTOR & GAMBLE COMPANY (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0650361-A1 | COMPOSITIONS FOR THE TREATMENT OF ARTHRITIS CONTAINING PHOSPHONATES AND NSAIDS | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1995-05-03 | — | — | EP | disclosed |
| WO-1994000130-A1 | COMPOSITIONS FOR THE TREATMENT OF ARTHRITIS CONTAINING PHOSPHONATES AND NSAIDS | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1994-01-06 | — | — | WO | disclosed |
| WO-1993024494-A1 | QUATERNARY NITROGEN-CONTAINING PHOSPHONATE COMPOUNDS, FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | THE PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1993-12-09 | — | — | WO | disclosed |