SCHEMBL8467608

SCHEMBL8467608

[c]1nc(Nc2ccccc2)nc(Nc2ccccc2)n1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.57
MEN1 O00255 3/20 0.57
KMT2A Q03164 3/20 0.57
GAA P10253 3/20 0.57
MAPK1 P28482 3/20 0.57
KDM4E B2RXH2 2/20 0.57
NFKB1 P19838 1/20 0.52
KCNH3 Q9ULD8 4/20 0.52
RECQL P46063 1/20 0.48
MCL1 Q07820 1/20 0.48
LMNA P02545 1/20 0.48
HSD17B10 Q99714 2/20 0.48
RAB9A P51151 2/20 0.47
ALDH1A1 P00352 2/20 0.47
CHEK1 O14757 1/20 0.47
IKBKB O14920 1/20 0.47
AURKA O14965 1/20 0.47
NPC1 O15118 1/20 0.47
PDPK1 O15530 1/20 0.47
CHEK2 O96017 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4649914 0.86 MAPT (0.63) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL4651692 0.86 AURKA (0.45) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL9183870 0.86 BCL6 (0.56) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL9004157 0.86 MEN1 (0.44) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL633400 0.83 MEN1 (0.77) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL10496305 0.80 MAPT (0.40) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL15422840 0.79 KCNH3 (0.64) MEN1KMT2AGAAKCNH3RECQL
SCHEMBL10492385 0.79 MAPT (0.42) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL27571766 0.79 RECQL (0.47) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL8466073 0.78 AURKA (0.50) MAPTMEN1KMT2AGAAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1833019-A Composition for treating textiles comprising a photobleaching component and a fluorescent whitening component PROCTER & GAMBLE (US) 2006-09-13 CN disclosed
US-5869184-A RESIN RAW MATERIALS FOR PAINTS, ADHESIVES MITSUI TOATSU CHEMICALS, INC. (JP) 1999-02-09 US disclosed
US-5744504-A AMINO RESIN; THERMOSETTING MOLDING MATERIALS MITSUI TOATSU CHEMICALS, INC. (JP) 1998-04-28 US disclosed