Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8468856 | 0.84 | KDM1A (0.45) | HTR2CMAPTKDM1AMAOAMAOB | |
| SCHEMBL9947171 | 0.78 | HTR2C (0.47) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| SCHEMBL9947173 | 0.78 | HTR2C (0.50) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| SCHEMBL9947168 | 0.76 | HTR2C (0.45) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| Hydrochloric Acid SCHEMBL8468775 | 0.74 | HTR2C (0.43) | HTR2CHTR2AHTR2BMAPTADRA1A | |
| SCHEMBL9947172 | 0.73 | HTR2C (0.44) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| SCHEMBL15763556 | 0.72 | HTR2C (0.41) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| SCHEMBL8333649 | 0.72 | HTR2C (0.63) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| Ammonia Solution, Strong SCHEMBL267089 | 0.71 | HTR2C (0.61) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| SCHEMBL8333645 | 0.68 | HTR2C (0.61) | HTR2CHTR2AHTR2BSLC9A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819705-B1 | Olefin polymerization | PHILLIPS PETROLEUM CO (US) | 1999-09-08 | — | — | EP | disclosed |