Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.61 |
| ▸ | PPARG | P37231 | 7/20 | 0.61 |
| ▸ | PPARD | Q03181 | 7/20 | 0.61 |
| ▸ | PPARA | Q07869 | 7/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.61 |
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | TLR2 | O60603 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | FABP4 | P15090 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.61 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ESR1 | P03372 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dodecanoate SCHEMBL975849 | 0.98 | GPR84 (0.59) | GPR84PPARGPPARDPPARAHDAC11 | |
| Nonanoate SCHEMBL30520295 | 0.98 | GPR84 (0.59) | GPR84PPARGPPARDPPARAHDAC11 | |
| Octanoic Acid SCHEMBL26607802 | 0.98 | GPR84 (0.59) | GPR84PPARGPPARDPPARAHDAC11 | |
| Octanoic Acid SCHEMBL2252436 | 0.98 | GPR84 (0.59) | GPR84PPARGPPARDPPARAHDAC11 | |
| Decanoic Acid SCHEMBL9138144 | 0.98 | GPR84 (0.59) | GPR84PPARGPPARDPPARAHDAC11 | |
| Stearic Acid SCHEMBL9356615 | 0.98 | GPR84 (0.59) | GPR84PPARGPPARDPPARAHDAC11 | |
| Hexanoate SCHEMBL11656156 | 0.96 | AKR1B1 (0.57) | GPR84PPARGPPARDPPARAHDAC11 | |
| Octanoic Acid SCHEMBL28232313 | 0.92 | GPR84 (0.52) | GPR84PPARGPPARDPPARAHDAC11 | |
| Valeric Acid SCHEMBL27444415 | 0.91 | ALDH1A1 (0.55) | GPR84PPARGPPARDPPARAHDAC11 | |
| Oleic Acid SCHEMBL2537967 | 0.89 | PPARG (0.66) | PPARGPPARDPPARATSHRPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942470-A | OIL SOLUBLE SULFUR CONTAINING PRESSURE AND ANTI-WEAR AGENT, AMINE SALT OF PHOSPHORUS ESTER, SUCCINIMIDE, AND ASHLESS DISPERSANTS | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1999-08-24 | — | — | US | disclosed |
| EP-0531585-B1 | Oil additive concentrates and lubricants of enhanced performance capabilities | ETHYL PETROLEUM ADDITIVES LTD (GB) | 1998-11-04 | — | — | EP | disclosed |
| EP-0531000-B1 | Oil additive concentrates and lubricants of enhanced performance capabilities | ETHYL PETROLEUM ADDITIVES INC (US) | 1997-02-05 | — | — | EP | disclosed |
| US-5464549-A | Oil soluble dispersants suitable for use in fuels and lubricants | ETHYL CORPORATION (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0459656-B1 | Lubricant compositions | ETHYL PETROLEUM ADDITIVES INC (US) | 1995-09-20 | — | — | EP | disclosed |
| US-5358652-A | Using 3,5-dihydrocarbyl-4-hydroxybenzylamine compound | ETHYL PETROLEUM ADDITIVES, LIMITED (GB) | 1994-10-25 | — | — | US | disclosed |
| EP-0428393-B1 | GEAR OILS AND ADDITIVES THEREFOR | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1993-10-06 | — | — | EP | disclosed |
| US-5241003-A | Post-treated polyisobutenyl succinimide; crankcase, transmission oils | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1993-08-31 | — | — | US | disclosed |
| EP-0531585-A1 | Oil additive concentrates and lubricants of enhanced performance capabilities | ETHYL PETROLEUM ADDITIVES LIMITED (GB) | 1993-03-17 | — | — | EP | disclosed |
| EP-0531000-A1 | Oil additive concentrates and lubricants of enhanced performance capabilities | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| US-5137980-A | Reacting polyisobutene with aacidic reactant; super atmospheric pressure; low tar rating | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1992-08-11 | — | — | US | disclosed |
| EP-0459656-A1 | Lubricant compositions | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1991-12-04 | — | — | EP | disclosed |
| EP-0430624-A1 | Gear oils and additives therefor | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1991-06-05 | — | — | EP | disclosed |
| EP-0428393-A1 | Gear oils and additives therefor | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1991-05-22 | — | — | EP | disclosed |