Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 13/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL11800520 | 0.98 | HDAC3 (0.48) | HDAC3HDAC1HDAC2MAPK1HDAC6 | |
| SCHEMBL6032044 | 0.84 | ALDH1A1 (0.42) | MAPK1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL1116302 | 0.80 | L3MBTL1 (0.61) | HDAC3HDAC1HDAC2MAPK1HDAC6 | |
| SCHEMBL10894670 | 0.80 | HDAC3 (0.57) | HDAC3HDAC1HDAC2MAPK1HDAC6 | |
| SCHEMBL24881745 | 0.78 | HDAC3 (0.60) | HDAC3HDAC1HDAC2MAPK1HDAC6 | |
| SCHEMBL11757742 | 0.78 | HDAC1 (0.50) | HDAC3HDAC1HDAC2MAPK1HDAC6 | |
| SCHEMBL8456184 | 0.78 | HDAC3 (0.50) | HDAC3HDAC1HDAC2MAPK1HDAC6 | |
| SCHEMBL11799525 | 0.77 | HDAC3 (0.53) | HDAC3HDAC1HDAC2MAPK1HDAC6 | |
| SCHEMBL11500810 | 0.76 | NPC1 (0.48) | MAPK1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL13568860 | 0.75 | HDAC3 (0.47) | HDAC3HDAC1HDAC2MAPK1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3935098-A | Adsorbent process for heavy metals | NIPPON SODA CO., LTD. (JA) | 1976-01-27 | — | — | US | claimed |
| US-7906541-B2 | Process to prepare new substituted 1H-benzo[d]imidazol-2(3H)-ones, new intermediates and their use as BACE 1 inhibitors | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2011-03-15 | — | — | US | disclosed |
| US-7906541-B2 | Process to prepare new substituted 1H-benzo[d]imidazol-2(3H)-ones, new intermediates and their use as BACE 1 inhibitors | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2011-03-15 | — | — | US | disclosed |
| WO-2010052670-A1 | PROCESS TO PREPARE NEW SUBSTITUTED 1H-BENZO [d] IMIDAZOL-2(3H)-ONES, NEW INTERMEDIATES AND THEIR USE AS BACE 1 INHIBITORS | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2010-05-14 | — | — | WO | disclosed |
| US-20100120880-A1 | PROCESS TO PREPARE NEW SUBSITUTED 1H-BENZO[d]IMIDAZOL-2(3H)-ONES, NEW INTERMEDIATES AND THEIR USE AS BACE 1 INHIBITORS | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2010-05-13 | — | — | US | disclosed |
| US-20100120880-A1 | PROCESS TO PREPARE NEW SUBSITUTED 1H-BENZO[d]IMIDAZOL-2(3H)-ONES, NEW INTERMEDIATES AND THEIR USE AS BACE 1 INHIBITORS | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2010-05-13 | — | — | US | disclosed |
| EP-2184276-A1 | Process to prepare new substituted 1H-Benzo(d) imidazol-2(3h)-Ones, New intermediates and their use as bace 1 inhibitors | UNIVERSITE PAUL CEZANNE AIX-MARSEILLE III (FR) | 2010-05-12 | — | — | EP | disclosed |
| CN-1052043-A | 2-PART HAIR DYEING AGENTS | SUNSTAR KK (JP) | 1991-06-12 | — | — | CN | disclosed |
| US-3985782-A | Phenylthiourea derivatives | RHONE-POULENC S.A. (FR) | 1976-10-12 | — | — | US | disclosed |
| US-3935098-A | Adsorbent process for heavy metals | NIPPON SODA CO., LTD. (JA) | 1976-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120880-A1 | PROCESS TO PREPARE NEW SUBSITUTED 1H-BENZO[d]IMIDAZOL-2(3H)-ONES, NEW INTERMEDIATES AND THEIR USE AS BACE 1 INHIBITORS | BACE1, BACE2, PSEN1 | HDAC3 1468/4885HDAC1 450/4885HDAC2 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.