Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.45 |
| ▸ | MMP3 | P08254 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1890106 | 0.99 | MMP8 (0.44) | MMP8MMP3ALDH1A1MMP1MMP2 | |
| Hydrochloric Acid SCHEMBL1890104 | 0.99 | MMP8 (0.44) | MMP8MMP3ALDH1A1MMP1MMP2 | |
| SCHEMBL297821 | 0.91 | MMP8 (0.46) | MMP8MMP3ALDH1A1MMP1MMP2 | |
| SCHEMBL297820 | 0.91 | MMP8 (0.46) | MMP8MMP3ALDH1A1MMP1MMP2 | |
| Hydrochloric Acid SCHEMBL1895243 | 0.90 | MMP8 (0.45) | MMP8MMP3ALDH1A1MMP1MMP2 | |
| Hydrochloric Acid SCHEMBL1895224 | 0.90 | MMP8 (0.45) | MMP8MMP3ALDH1A1MMP1MMP2 | |
| SCHEMBL296254 | 0.89 | MMP3 (0.47) | MMP8MMP3ALDH1A1MMP1MMP2 | |
| SCHEMBL296253 | 0.89 | MMP3 (0.47) | MMP8MMP3ALDH1A1MMP1MMP2 | |
| Hydrochloric Acid SCHEMBL4452524 | 0.88 | HDAC1 (0.46) | MMP8MMP3ALDH1A1MMP1MMP2 | |
| Hydrochloric Acid SCHEMBL4452530 | 0.88 | HDAC1 (0.46) | MMP8MMP3ALDH1A1MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785659-B2 | Method for the production of sulphonylpyrroles as HDAC inhibitors | 4SC AG (DE) | 2014-07-22 | — | — | US | disclosed |
| US-8785659-B2 | Method for the production of sulphonylpyrroles as HDAC inhibitors | 4SC AG (DE) | 2014-07-22 | — | — | US | disclosed |
| EP-2265580-B1 | NOVEL METHOD FOR THE PRODUCTION OF SULPHONYLPYRROLES AS HDAC INHIBITORS | 4SC AG (DE) | 2011-08-10 | — | — | EP | disclosed |
| US-20110105568-A1 | NOVEL METHOD FOR THE PRODUCTION OF SULPHONYLPYRROLES AS HDAC INHIBITORS | 4SC AG (DE) | 2011-05-05 | — | — | US | disclosed |
| US-20110105568-A1 | NOVEL METHOD FOR THE PRODUCTION OF SULPHONYLPYRROLES AS HDAC INHIBITORS | 4SC AG (DE) | 2011-05-05 | — | — | US | disclosed |
| WO-2009112529-A1 | NOVEL METHOD FOR THE PRODUCTION OF SULPHONYLPYRROLES AS HDAC INHIBITORS | 4SC AG (DE) | 2009-09-17 | — | — | WO | disclosed |
| EP-2100878-A1 | Novel method for the production of sulphonylpyrroles as HDAC inhibitors | 4SC AG (DE) | 2009-09-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105568-A1 | NOVEL METHOD FOR THE PRODUCTION OF SULPHONYLPYRROLES AS HDAC INHIBITORS | HDAC1, HDAC2, HDAC3 | MMP8 3535/4885MMP3 2777/4885ALDH1A1 270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.