Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | RARB | P10826 | 1/20 | 0.50 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL5862959 | 1.00 | NAAA (0.65) | NAAASIGMAR1CES2CES1EPHX1 | |
| Benzoic Acid SCHEMBL32671576 | 1.00 | NAAA (0.65) | NAAASIGMAR1CES2CES1EPHX1 | |
| Benzoic Acid SCHEMBL5862551 | 0.93 | NAAA (0.54) | NAAASIGMAR1CES2CES1HTT | |
| Benzoic Acid SCHEMBL31357355 | 0.92 | NAAA (0.56) | NAAASIGMAR1CES2CES1EPHX1 | |
| Dodecane SCHEMBL29930922 | 0.89 | TSHR (0.64) | NAAACES2CES1ALDH1A1TSHR | |
| Benzoic Acid SCHEMBL9089056 | 0.89 | TSHR (0.64) | NAAACES2CES1ALDH1A1TSHR | |
| Undecane SCHEMBL15129102 | 0.89 | TSHR (0.64) | NAAACES2CES1ALDH1A1TSHR | |
| Benzoic Acid SCHEMBL8371517 | 0.89 | TSHR (0.64) | NAAACES2CES1ALDH1A1TSHR | |
| Dodecane SCHEMBL28594534 | 0.89 | TSHR (0.64) | NAAACES2CES1ALDH1A1TSHR | |
| Hexadecane SCHEMBL28733004 | 0.89 | TSHR (0.64) | NAAACES2CES1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942470-A | OIL SOLUBLE SULFUR CONTAINING PRESSURE AND ANTI-WEAR AGENT, AMINE SALT OF PHOSPHORUS ESTER, SUCCINIMIDE, AND ASHLESS DISPERSANTS | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1999-08-24 | — | — | US | disclosed |
| EP-0531585-B1 | Oil additive concentrates and lubricants of enhanced performance capabilities | ETHYL PETROLEUM ADDITIVES LTD (GB) | 1998-11-04 | — | — | EP | disclosed |
| EP-0531000-B1 | Oil additive concentrates and lubricants of enhanced performance capabilities | ETHYL PETROLEUM ADDITIVES INC (US) | 1997-02-05 | — | — | EP | disclosed |
| US-5464549-A | Oil soluble dispersants suitable for use in fuels and lubricants | ETHYL CORPORATION (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0459656-B1 | Lubricant compositions | ETHYL PETROLEUM ADDITIVES INC (US) | 1995-09-20 | — | — | EP | disclosed |
| US-5358652-A | Using 3,5-dihydrocarbyl-4-hydroxybenzylamine compound | ETHYL PETROLEUM ADDITIVES, LIMITED (GB) | 1994-10-25 | — | — | US | disclosed |
| EP-0428393-B1 | GEAR OILS AND ADDITIVES THEREFOR | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1993-10-06 | — | — | EP | disclosed |
| US-5241003-A | Post-treated polyisobutenyl succinimide; crankcase, transmission oils | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1993-08-31 | — | — | US | disclosed |
| EP-0531585-A1 | Oil additive concentrates and lubricants of enhanced performance capabilities | ETHYL PETROLEUM ADDITIVES LIMITED (GB) | 1993-03-17 | — | — | EP | disclosed |
| EP-0531000-A1 | Oil additive concentrates and lubricants of enhanced performance capabilities | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| US-5137980-A | Reacting polyisobutene with aacidic reactant; super atmospheric pressure; low tar rating | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1992-08-11 | — | — | US | disclosed |
| EP-0459656-A1 | Lubricant compositions | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1991-12-04 | — | — | EP | disclosed |
| EP-0430624-A1 | Gear oils and additives therefor | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1991-06-05 | — | — | EP | disclosed |
| EP-0428393-A1 | Gear oils and additives therefor | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1991-05-22 | — | — | EP | disclosed |