Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 14/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL847630 | 0.84 | TRPV1 (0.53) | TRPV1RAB9AHSD17B10POLBLMNA | |
| SCHEMBL846245 | 0.83 | TRPV1 (0.56) | TRPV1RAB9AHSD17B10POLBLMNA | |
| SCHEMBL651159 | 0.79 | KDR (0.74) | TRPV1RAB9AHSD17B10POLBLMNA | |
| SCHEMBL10077508 | 0.77 | TRPV1 (0.54) | TRPV1RAB9AHSD17B10POLBLMNA | |
| SCHEMBL846477 | 0.76 | KDR (0.59) | TRPV1RAB9AHSD17B10POLBLMNA | |
| SCHEMBL20509078 | 0.74 | HDAC1 (0.76) | TRPV1RAB9AHSD17B10POLBLMNA | |
| SCHEMBL846516 | 0.73 | TRPV1 (0.65) | TRPV1RAB9AHSD17B10POLBLMNA | |
| SCHEMBL846491 | 0.73 | TRPV1 (0.71) | TRPV1RAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL29432899 | 0.72 | POLB (0.61) | TRPV1RAB9AHSD17B10POLBLMNA | |
| SCHEMBL19832640 | 0.72 | POLB (0.61) | TRPV1RAB9AHSD17B10POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |