Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 1/20 | 0.41 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8469011 | 1.00 | SLC5A1 (0.41) | SLC5A1SLC5A2MGLLSIGMAR1MAOA | |
| SCHEMBL8331603 | 0.86 | HTR2A (0.43) | MGLLMAOA | |
| SCHEMBL8331482 | 0.86 | HTR2C (0.43) | OPRM1 | |
| SCHEMBL8331359 | 0.86 | HTR2A (0.43) | OPRM1 | |
| SCHEMBL8332820 | 0.85 | KDM1A (0.43) | — | |
| SCHEMBL8332792 | 0.85 | HTR2A (0.43) | — | |
| SCHEMBL8330943 | 0.84 | MAOA (0.49) | SIGMAR1MAOASMN1; SMN2OPRM1 | |
| SCHEMBL8330940 | 0.84 | MAOA (0.49) | SIGMAR1MAOASMN1; SMN2OPRM1 | |
| SCHEMBL8332882 | 0.82 | HTR2A (0.47) | SIGMAR1 | |
| SCHEMBL8329351 | 0.82 | HTR2A (0.47) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889031-A | CONTROLLING CIRCADIAN RHYTHMS | BRISTOL-MYERS SQUIBB COMPNAY (US) | 1999-03-30 | — | — | US | disclosed |
| US-5753709-A | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-19 | — | — | US | disclosed |