Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846902 | 1.00 | NAMPT (0.43) | NAMPTKDM4EMAPTLMNAALDH1A1 | |
| SCHEMBL846239 | 0.82 | NAMPT (0.47) | NAMPTKDM4EMAPTLMNAALDH1A1 | |
| SCHEMBL846240 | 0.82 | NAMPT (0.47) | NAMPTKDM4EMAPTLMNAALDH1A1 | |
| SCHEMBL847499 | 0.82 | MAOB (0.37) | KDM4EMAPTLMNAALDH1A1RAB9A | |
| SCHEMBL847498 | 0.82 | MAOB (0.37) | KDM4EMAPTLMNAALDH1A1RAB9A | |
| SCHEMBL13991503 | 0.75 | RAB9A (0.65) | NAMPTKDM4EMAPTLMNAALDH1A1 | |
| SCHEMBL16101601 | 0.75 | KDR (0.60) | NAMPTKDM4EMAPTLMNAALDH1A1 | |
| SCHEMBL13991500 | 0.75 | KDR (0.60) | NAMPTKDM4EMAPTLMNAALDH1A1 | |
| SCHEMBL846550 | 0.73 | DHODH (0.53) | NAMPTKDM4EMAPTLMNAALDH1A1 | |
| SCHEMBL846549 | 0.73 | DHODH (0.53) | NAMPTKDM4EMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |