Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 5/20 | 0.36 |
| ▸ | MMP2 | P08253 | 5/20 | 0.36 |
| ▸ | MMP9 | P14780 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL847498 | 1.00 | MAOB (0.37) | MAOBMAOAMMP1MMP2MMP9 | |
| SCHEMBL846792 | 0.83 | MMP1 (0.42) | MAOBMAOAMMP1MMP2MMP9 | |
| SCHEMBL846791 | 0.83 | MMP1 (0.42) | MAOBMAOAMMP1MMP2MMP9 | |
| SCHEMBL846902 | 0.82 | NAMPT (0.43) | RAB9AKMT2ANPC1SMN1; SMN2LMNA | |
| SCHEMBL846903 | 0.82 | NAMPT (0.43) | RAB9AKMT2ANPC1SMN1; SMN2LMNA | |
| SCHEMBL846660 | 0.73 | NPC1 (0.56) | MAOBMMP1MMP2MMP9RAB9A | |
| SCHEMBL846661 | 0.73 | NPC1 (0.56) | MAOBMMP1MMP2MMP9RAB9A | |
| SCHEMBL846918 | 0.70 | RAB9A (0.44) | MAOBMMP1MMP2MMP9RAB9A | |
| SCHEMBL846919 | 0.70 | RAB9A (0.44) | MAOBMMP1MMP2MMP9RAB9A | |
| SCHEMBL846230 | 0.70 | MAPT (0.56) | MMP1MMP2MMP9RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |