Sugi Predict

Sugi Predict / Compounds / SCHEMBL8469059

SCHEMBL8469059

SCHEMBL8469059

CCOC(=O)C(Cc1ccc2ccccc2c1)C(=O)OCC

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PPARG P37231 3/20 0.56
▸ PPARD Q03181 3/20 0.56
▸ PPARA Q07869 3/20 0.56
▸ MMP8 P22894 1/20 0.52
▸ HTR2A P28223 1/20 0.50
▸ HTR2C P28335 1/20 0.50
▸ HTR2B P41595 1/20 0.50
▸ TACR1 P25103 1/20 0.50
▸ CYP1A2 P05177 1/20 0.49
▸ CYP2A6 P11509 1/20 0.49
▸ ALDH1A1 P00352 1/20 0.47
▸ TP53 P04637 1/20 0.47
▸ GAA P10253 1/20 0.47
▸ TDP1 Q9NUW8 2/20 0.47
▸ MME P08473 1/20 0.45
▸ ACE P12821 1/20 0.45
▸ CPA1 P15085 1/20 0.45
▸ ACE2 Q9BYF1 1/20 0.45
▸ TSHR P16473 1/20 0.45
▸ MAPK1 P28482 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9129089 0.93 TACR1 (0.50) PPARGPPARDPPARAMMP8HTR2A
SCHEMBL9592092 0.91 PPARG (0.48) PPARGPPARDPPARAMMP8HTR2A
SCHEMBL9592711 0.89 PPARG (0.46) PPARGPPARDPPARAMMP8HTR2A
SCHEMBL23257472 0.86 HTR2A (0.53) PPARGPPARDPPARAMMP8HTR2A
SCHEMBL23015424 0.86 HTR2A (0.53) PPARGPPARDPPARAMMP8HTR2A
SCHEMBL22231523 0.86 PPARG (0.72) PPARGPPARDPPARAMMP8HTR2A
SCHEMBL839749 0.85 HTR2A (0.55) HTR2AHTR2CHTR2BTACR1CYP1A2
SCHEMBL22334925 0.85 TACR1 (0.48) PPARGPPARDPPARAMMP8HTR2A
SCHEMBL839943 0.85 HTR2A (0.55) HTR2AHTR2CHTR2BTACR1CYP1A2
SCHEMBL27452777 0.84 TACR1 (0.50) PPARGPPARDPPARAMMP8TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11072588-B2 Barbituric acid derivatives comprising cationic and lipophilic groups Universitetet I Tromsø—Norges Arktiske Universitet (NO) 2021-07-27 — — US disclosed
CN-108473520-B Catalyst comprising a metallocene complex and a cocatalyst SABIC环球技术有限责任公司 2021-07-23 — — CN disclosed
US-11040995-B2 Catalyst comprising a metallocene complex and co-catalyst SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2021-06-22 — — US disclosed
US-11040995-B2 Catalyst comprising a metallocene complex and co-catalyst SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2021-06-22 — — US disclosed
US-20200270292-A1 CATALYST COMPRISING A METALLOCENE COMPLEX AND CO-CATALYST SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2020-08-27 — — US disclosed
US-20200270292-A1 CATALYST COMPRISING A METALLOCENE COMPLEX AND CO-CATALYST SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2020-08-27 — — US disclosed
EP-3601234-A1 BARBITURIC ACID DERIVATIVES COMPRISING CATIONIC AND LIPOPHILIC GROUPS Universitetet i Tromsø - Norges Arktiske Universitet (NO) 2020-02-05 — — EP disclosed
CN-110337435-A Barbituric acid derivatives comprising cation group and lipophilic group 特罗姆瑟大学-挪威北极圈大学 2019-10-15 — — CN disclosed
EP-3400230-B1 CATALYST COMPRISING A METALLOCENE COMPLEX AND A CO-CATALYST SABIC GLOBAL TECHNOLOGIES BV (NL) 2019-09-11 — — EP disclosed
EP-3400230-A1 CATALYST COMPRISING A METALLOCENE COMPLEX AND A CO-CATALYST SABIC Global Technologies B.V. (NL) 2018-11-14 — — EP disclosed
CN-1069707-C Novel polyolefin fibers and their fabrics EXXON CHEMICAL PATENTS INC (US) 2001-08-15 — — CN disclosed
US-5932669-A HOMO OR COPOLYMERIZING OLEFIN IN PRESENCE OF TRANSITIONAL METAL COMPOUND AS A METALLOCENE CATALYST AND ALUMINOXANE AS COCATALYST TARGOR GMBH (DE) 1999-08-03 — — US disclosed
CN-1043474-C Supported metallocene catalyst systems for polymerization of olefins, preparation and use thereof EXXON CHEMICAL PATENTS INC (US) 1999-05-26 — — CN disclosed
US-5830821-A POLYMERIZATION CATALYST TARGOR GMBH (DE) 1998-11-03 — — US disclosed
CN-1179784-A Method for producing prepolymerized catalyst EXXON CHEMICAL PATENTS INC (US) 1998-04-22 — — CN disclosed
EP-0510526-B1 Use of sulfonamides as drug and new sulfonamides HOFFMANN LA ROCHE (CH) 1996-12-04 — — EP disclosed
CN-1130912-A Supported metallocene catalyst systems for polymerization of olefins, preparation and use thereof EXXON CHEMICAL PATENTS INC (US) 1996-09-11 — — CN disclosed
CN-1128055-A Novel polyolefin fiber and fabric thereof EXXON CHEMICAL PATENTS INC (US) 1996-07-31 — — CN disclosed
US-5455366-A Olefin polymerization catalysts HOECHST AG (DE) 1995-10-03 — — US disclosed
EP-0510526-A1 Use of sulfonamides as drug and new sulfonamides F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) 1992-10-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11072588-B2 Barbituric acid derivatives comprising cationic and lipophilic groups NGLY1, CATSPER1, BID PPARG 3810/4885PPARD 3031/4885PPARA 2986/4885
US-11040995-B2 Catalyst comprising a metallocene complex and co-catalyst CCRL2, UBE2L3, MAL2 PPARG 3149/4885PPARD 3953/4885PPARA 3438/4885
US-20200270292-A1 CATALYST COMPRISING A METALLOCENE COMPLEX AND CO-CATALYST LAS1L, CCNE2, CKS2 PPARG 3627/4885PPARD 4154/4885PPARA 3696/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.